Structure of PDB 6p5n Chain AP Binding Site BS02

Receptor Information

>6p5n Chain AP (length=153) Species: 9986 (Oryctolagus cuniculus)

VRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDV
TLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESN
AELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILT
EKE

Ligand information

>6p5n Chain 8 (length=151)

cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagc
uagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaac
gcacuugcggccccggguuccucccggggcuacgccugucugagcgucgc
u

.........................................<<<<<<.<<
.....>>>.....(.<<<......>>........>>>..)...>>>....
<<<..>>><<<<<<<<.......>>>>>>>>...................
.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6p5n The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): R3 S5 R61 R62 W78 N120 K121 P123 H145
• Binding residue (residue number reindexed from 1): R2 S4 R60 R61 W77 N119 K120 P122 H144

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6p5n, PDBe:6p5n, PDBj:6p5n
• PDBsum: 6p5n
• PubMed: 31609474
• UniProt: G1SCJ6|RL17_RABIT Large ribosomal subunit protein uL22 (Gene Name=RPL17)