Structure of PDB 8ois Chain AO Binding Site BS02

Receptor Information

>8ois Chain AO (length=193) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PISPYKDEPWKYLESEEYQERYGSRPVWADYRRNHKGGVPPQRTRKTCIR
RNKVVGNPCPICRDHKLHVDFRNVKLLEQFVCAHTGIIFYAPYTGVCVKQ
HKRLTQAIQKARDHGLLIYHIPQVEPRDLDFSTSHGAVSATPPAPTLVSG
DPWYPWYNWKQPPERELSRLRRLYQGHLQEESGPPPESMPKMP

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8ois Chain AO Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8ois Molecular basis of translation termination at noncanonical stop codons in human mitochondria.
Resolution	3.0 Å
Binding residue (original residue number in PDB)	C94 C105 C108 C143
Binding residue (residue number reindexed from 1)	C48 C59 C62 C97
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0006412	translation
GO:0032543	mitochondrial translation

	Cellular Component
GO:0005654	nucleoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005763	mitochondrial small ribosomal subunit
GO:0005840	ribosome
GO:0030054	cell junction
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8ois, PDBe:8ois, PDBj:8ois
PDBsum	8ois
PubMed	37141370
UniProt	Q9Y676\|RT18B_HUMAN Small ribosomal subunit protein mS40 (Gene Name=MRPS18B)

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