Structure of PDB 8q5i Chain AI Binding Site BS02

Receptor Information

>8q5i Chain AI (length=119) Species: 5476 (Candida albicans)

AGVKTFELRTKSKEQLESQLVELKQELATLKVQKLQRPSLPRIHTVRKNI
ARVLTVINLNQRENVRAFYAGKKYIPKDLRAKKTRALRRKLTKFEASQET
EKARKQRIAFPQRKFAIKA

Ligand information

>8q5i Chain 4 (length=158)

aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagc
gaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucu
uugaacgcacauugcgcccucugguauuccggagggcaugccuguuugag
cgucguuu

.........................................<<<<<<.((
.....>>>.....<.<<<<.....))............>>.>>..>...>
>>....<<.....>><<<<<<<<<....>>>>>>>>>.............
........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8q5i Structural characterization of cephaeline binding to the eukaryotic ribosome using Cryo-Electron Microscopy
• Resolution: 2.45 Å
• Binding residue (original residue number in PDB): G3 K5 T6 F7 R10 K35 S40 L41 P42 H45 R48 K49 A52 R53 L55 T56 N59 R63 K78 R81 A82 K83 T85 R86 R89
• Binding residue (residue number reindexed from 1): G2 K4 T5 F6 R9 K34 S39 L40 P41 H44 R47 K48 A51 R52 L54 T55 N58 R62 K77 R80 A81 K82 T84 R85 R88

Gene Ontology

Molecular Function

• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8q5i, PDBe:8q5i, PDBj:8q5i
• PDBsum: 8q5i
• UniProt: A0A8H6F6B7