Structure of PDB 7q0p Chain AI Binding Site BS02

Receptor Information

>7q0p Chain AI (length=119) Species: 237561 (Candida albicans SC5314)

AGVKTFELRTKSKEQLESQLVELKQELATLKVQKLQRPSLPRIHTVRKNI
ARVLTVINLNQRENVRAFYAGKKYIPKDLRAKKTRALRRKLTKFEASQET
EKARKQRIAFPQRKFAIKA

Ligand information

>7q0p Chain 4 (length=158)

aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagc
gaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucu
uugaacgcacauugcgcccucugguauuccggagggcaugccuguuugag
cgucguuu

.........................................<<<<<<.((
.....>>>.....<.<<<<.....))............>>.>>..>...>
>>....<<.....>><<<<<<<<<....>>>>>>>>>.............
........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7q0p E-site drug specificity of the human pathogen Candida albicans ribosome.
• Resolution: 2.77 Å
• Binding residue (original residue number in PDB): A2 G3 K5 T6 F7 R10 K35 R43 H45 R48 K49 A52 R53 L55 T56 N59 L60 R63 K78 A82 K83 T85 R86 R89
• Binding residue (residue number reindexed from 1): A1 G2 K4 T5 F6 R9 K34 R42 H44 R47 K48 A51 R52 L54 T55 N58 L59 R62 K77 A81 K82 T84 R85 R88

Gene Ontology

Molecular Function

• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7q0p, PDBe:7q0p, PDBj:7q0p
• PDBsum: 7q0p
• PubMed: 35613268
• UniProt: A0A1D8PK30|RL35_CANAL Large ribosomal subunit protein uL29 (Gene Name=RPL35)