Structure of PDB 6uz7 Chain AG Binding Site BS02

Receptor Information

>6uz7 Chain AG (length=233) Species: 28985 (Kluyveromyces lactis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NPLTKSSPRNFGIGQAIQPKRNLSRYVKWPEYVRLQRQKKILSIRLKVPP
SIAQFQNTLDRNTAAETFKLLKKYSPETAAEKKERLTKEAAAIAEGKTKQ
EASPKPYVVKYGLNHVVSLIENKKAKLVLIANDVDPIELVIFLPALCKKM
GVPYAIVKGKARLGTLVNQKTSAVAALTEVREEDEAALAKLVSTINANYL
EKYEDSKKHWGGGIMGQKAQKKIEKRAKAAESA

Ligand information

>6uz7 Chain 8 (length=157) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagc
gaauugcgauauguauugugaauugcagauuuucgugaaucaucaaaucu
uugaacgcacauugcgcccucugguauuccagggggcaugccuguuugag
cgucauu

.........................................<<<<<<.<<
.....>>>.....<..<<......>>..............>>...>...>
>>....<<.....>><<<<<<<<<....>>>>>>>>>.............
.......

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6uz7 Long-range interdomain communications in eIF5B regulate GTP hydrolysis and translation initiation.
Resolution	3.6 Å
Binding residue (original residue number in PDB)	Y54 Q58 R59 K62 K180 R184
Binding residue (residue number reindexed from 1)	Y32 Q36 R37 K40 K158 R162

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003723	RNA binding

	Biological Process
GO:0000470	maturation of LSU-rRNA
GO:0042254	ribosome biogenesis

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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External links

PDB	RCSB:6uz7, PDBe:6uz7, PDBj:6uz7
PDBsum	6uz7
PubMed	31900355
UniProt	B4UN96

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