Structure of PDB 6lqs Chain AG Binding Site BS02

Receptor Information
>6lqs Chain AG (length=826) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QYKLSVVSGGKPALNNLSSVTGNKNIARLSQDQRNYIIPFNNQIKVYSVE
TRQCVKTLKFANNSLLSGIFLQEEENNESIVKILLGDITVPQQAHLITVF
TNNGHVIVLNYKGKLVESPKHFKISLADEKLANVFHSEGNYRILTTFKHN
SLQSYRLYALTFDDAKKQFEVAHQAEWHNVILSNISSNGKLLAHMCKDVE
HKSISVVSLFDDSVNLSFPLGSILSSQTQSLSYNTRYVSSMAIDNMGQQL
AVGFASGVISIVSLADLQIRLLKWHIDSVLSLSFSHDGSYLLSGGWEKVM
SLWQLETNSQQFLPRLNGIIIDCQVLGPQGNYYSLILQMTENNSNSDYQF
LLLNASDLTSKLSINGPLPVFNSTIKHIQQPISAMNTKNSNSITSLNHSK
KKQSRKLIKSRRQDFTTNVEINPINKNLYFPHISAVQIFDFYKNEQVNYQ
YLTSGVNNSMGKVRFELNLQDPIITDLKFTKDGQWMITYEIEYPPNDLLS
SKDLTHILKFWTKNDNETNWNLKTKVINPHGISVPITKILPSPRSVNNSQ
GCLTADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSLAWSQDGSL
IFHGFDDKLQILDFDTFKKFESLENTKTVSEFTLDSEIQTVKLINDTNLI
VATRTTLNAINLLRGQVINSFDLYPFVNGVYKNGHMDRLITCDERTGNIA
LVINQQLTDVPTINYKSRIIIFDSDLSTKLGNFTHHEYISWIGWNYDTDF
IFLDIESTLGVVGTNSDIFAEQLHKLSSDEEDIALEFINGEKKDKLVNMN
SFTSMFDNIQNVQMDTFFDRVMKVLT
Ligand information
>6lqs Chain 5A (length=152) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugcgaaagcaguugaagacaaguggcuugucguucguuaauggccucgca
gcgaaggauuugguggauuacuagcuaauagcaaucuaggaaacucaaag
agugcuaugcggagugcgcgagagcauuuccggcagcagagauuucagcu
gu
<<<....>>>...<<<<<<<<<...>>>>>>.>>>...............
.......................<<<...>>>..................
.........<<<<<<<<......>>>>.>>>>.<<<<.<<<..>>>.>>>
>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6lqs Cryo-EM structure of 90 S small ribosomal subunit precursors in transition states.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		H165 N166 S167 I197 M211 K213 Q248 T249 Y254 Y258 V259 F275 S277 V279 K294 W295 H296 E318 V320 Q332 F333 L334 P335 L417 N418 K422 R426 K427 R433 G482 S554 P556 F607 N609 K703 N704
Binding residue
(residue number reindexed from 1)		H149 N150 S151 I181 M195 K197 Q227 T228 Y233 Y237 V238 F254 S256 V258 K273 W274 H275 E297 V299 Q311 F312 L313 P314 L396 N397 K401 R405 K406 R412 G461 S533 P535 F586 N588 K682 N683
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0034511 U3 snoRNA binding
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:2000234 positive regulation of rRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005777 peroxisome
GO:0030686 90S preribosome
GO:0032040 small-subunit processome
GO:0033553 rDNA heterochromatin
GO:0034455 t-UTP complex
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6lqs, PDBe:6lqs, PDBj:6lqs
PDBsum6lqs
PubMed32943522
UniProtQ02931|UTP17_YEAST NET1-associated nuclear protein 1 (Gene Name=NAN1)

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