Structure of PDB 6uz7 Chain AF Binding Site BS02

Receptor Information
>6uz7 Chain AF (length=222) Species: 28985 (Kluyveromyces lactis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QKTAEQVAAERVARKAEKRAAILERNAAYQKEYETAERAVIDAKREAKAN
SSYYVSAEAKLVFVVRIKGINKIPPKPRKVLQLLRLNQINSGTFVKVTKA
TSELLKLIEPYVAYGYPSYSTVRQLVYKRGYGKINKQRIPLSDNSIVEAN
LGNYGILSVDDLIHEIVTVGPHFKQANNFLWPFKLSNPSGGWGVPRKFKH
FIQGGSFGNREEFINKLVKSMN
Ligand information
>6uz7 Chain 7 (length=121) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacugu
aguuaagcugguaagagccugaccgaguaguguagugggugaccauacgc
gaaacucaggugcugcaaucu
<<<<<<<<<....<<<<<<<<.....<<.<<..............>>...
.>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>
.....>>>>>>>>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB6uz7 Long-range interdomain communications in eIF5B regulate GTP hydrolysis and translation initiation.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		E128 R215 K218 I221 Q222
Binding residue
(residue number reindexed from 1)		E109 R196 K199 I202 Q203
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular Component
GO:0022625 cytosolic large ribosomal subunit

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Biological Process
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Cellular Component
External links
PDB RCSB:6uz7, PDBe:6uz7, PDBj:6uz7
PDBsum6uz7
PubMed31900355
UniProtQ6CS71

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