Structure of PDB 6lqq Chain AE Binding Site BS02

Receptor Information
>6lqq Chain AE (length=1534) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSLSDQLAQVASNNATVALDRKRRQKLHSASLIYNSKTAATQDYDFIFEN
ASKALEELSQIEPKFAIFSRTLFSESSISLDRNVQTKEEIKDLDNAINAY
LLLASSKWYLAPTLHATEWLVRRFQIHVKNTEMLLLSTLNYYQTPVFKRI
LSIIKLPPLFNCLSNFVRSEKPPTALTMIKLFNDMDFLKLYTSYLDQCIK
HNATYTNQLLFTTCCFINVVAFNSNNDEKLNQLVPILLEISAKLLASKSK
DCQIAAHTILVVFATALPLKKTIILAAMETILSNLDAKEAKHSALLTICK
LFQTLKGQGNVDQLPSKIFKLFDSKFDTVSILTFLDKEDKPVCDKFITSY
TRSIARYDRSKLNIILSLLKKIRLERYEVRLIITDLIYLSEILEDKSQLV
ELFEYFISINEDLVLKCLKSLGLTGELFEIRASFQTFLDKHSELINTTNV
SMLTETGERYKKVLSLFTEAIGKGYKASSFLTSFFTTLESRITFLLRVTI
SPAAPTALKLISLNNIAKYINSIEKEVNIFTLVPCLICALRDASIKVRTG
VKKILSLIAKRPSTKHYFLSDKLYGENVTIPMLNPKDSEAWLSGFLNEYV
TENYDISRILTPKRNEKVFLMFWANQALLIPSPYAKTVLLDNLNKSPTYA
SSYSSLFEEFISHYLENRSSWEKSCIANKTNFEHFERSLVNLVSPKEKQS
FMIDFVLSALNSDYEQLANIAAERLISIFASLNNAQKLKIVQNIVDSSSN
VESSYDTVGVLQSLPLDSDIFVSILNQRSSTSKNAFLKEEVALDKVRNVG
SEKGGLPVLYAQETLIYLKEHGCTELTNVRASPQVQNKLLLVIGSLEVIL
HSVMPIFTFMGPALIKNSKGNEKEEMHVPRHRRVKLFSTLVKALGSFLFL
ILVNFKIGEARILIEFHVNEELSGLNDLLDIIKLLTSSKSSSEKKKSLES
RDYYDVRRNLRLKVYSVLDKKLIRNIRVELTFSCITSQENEEASDSETHT
TEIKEILFKVLGNVVDEFVNAVLPLLSTSTNEDIRYHLTLVIGSKFELEG
SEAIPIVNNVMKVLLDRMPLESKSVVISQVILNTMTALVSKYGSILTQAL
TLATEKVSSDMTEVKISSLALITNCVQVLGVKSIAFYPKIVPPSIKLFDA
SLADSSNPLKEQLQVAILLLFAGLIKRIPSFLMSNILDVLHVIYFSREVD
SSIRLSVISLIIENIDLKEVLKVLFRIWSTEIATSNDTVAVSLFLSTLES
TVENIDKKSATSQSPIFFKLLLSLFEFRSISSFDNNTISRIEASVHEISN
SYVLKMNDKVFRPLFVILVRWAFDGEGVTNAGITETERLLAFFKFFNKLQ
ENLRGIITSYFTYLLEPVDMLLKRFISKDMENVNLRRLVINSLTSSLKFD
RDEYWKSTSRFELISVSLVNQLSNIENSIGKYLVKAIGALASNNSGVDEH
NQILNKLIVEHMKASCSSNEKLWAIRAMKLIYSKIGESWLVLLPQLVPVI
AELLEDDDEEIEREVRTGLVKVVENVLGEPFDRY
Ligand information
>6lqq Chain 5A (length=375) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugcgaaagcaguugaagacaaguggcuugucguucguuaaaauggccucg
ucaaacggugguacagcguguuuaauugacauggguugauaaccugaaca
gucucaucguggccauuggugagcagcgaaggauuugguggauuacuagc
uaauagcaaucuauuucaaagaauucaaacuugggggaaugccuuguuga
auagccggucgcaagacugugauucuucaaguguaaccuccucucuauca
aacguaccgguaucuguuuggugggaaacucaaagagugcuaugguaugg
ugacggagugcgcuggucaagaguguaaaagcuuuuugaacagagagcau
uuccggcagcagagauuucagcugu
<<<....>>>...<<<<<<<<<<.>>>>>>>.>>>..............<
<<<<<<<.<<...>>.>>>......>>>>>..<<<<<<.>>>>>>.....
..<<<<<<<<<..>>>.>>>>>>.........................<<
<...>>>.........................<<<<<..<<<<<<<..<<
<<...<<<<<....>>>>>.>.>>>..>>>>.>>.>>>>>>....<<<<<
<<<<<<<..>>>.>.>>>>>>>>...........................
...<<<<.<<<.<<<.<<<<<<<<......>>>>.>>>>.>>>...>>>.
.>>>><<<<<.<<<..>>>.>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6lqq Cryo-EM structure of 90 S small ribosomal subunit precursors in transition states.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		K23 R169
Binding residue
(residue number reindexed from 1)		K22 R168
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0030515 snoRNA binding
GO:0034511 U3 snoRNA binding
Biological Process
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
GO:0045943 positive regulation of transcription by RNA polymerase I
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0030686 90S preribosome
GO:0030688 preribosome, small subunit precursor
GO:0032040 small-subunit processome
GO:0033553 rDNA heterochromatin
GO:0034455 t-UTP complex
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6lqq, PDBe:6lqq, PDBj:6lqq
PDBsum6lqq
PubMed32943522
UniProtP42945|UTP10_YEAST U3 small nucleolar RNA-associated protein 10 (Gene Name=UTP10)

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