Structure of PDB 6s47 Chain AD Binding Site BS02

Receptor Information

>6s47 Chain AD (length=252) Species: 4932 (Saccharomyces cerevisiae)

GRVIRNQRKGAGSIFTSHTRLRQGAAKLRTLDYAERHGYIRGIVKQIVHD
SGRGAPLAKVVFRDPYKYRLREEIFIANEGVHTGQFIYAGKKASLNVGNV
LPLGSVPEGTIVSNVEEKPGDRGALARASGNYVIIIGHNPDENKTRVRLP
SGAKKVISSDARGVIGVIAGGGRVDKPLLKAGRAFHKYRLKRNSWPKTRG
VAMNPVDHPHGGGNHQHIGKASTISRGAVSGQKAGLIAARRTGLLRGSQK
TQ

Ligand information

>6s47 Chain BA (length=1707)

uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacu
gugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaaga
gauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauuc
auaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaa
auuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuu
caacggguaacggggaauaaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccu
aauucagggagguagugacaauaaauaacgauacagggcccauucggguc
uuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauugga
gggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguau
auuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguu
ggccaacggggccuuuccuucuggccaggacuuuuacuuugaaaaaauua
gaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauag
aauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugau
uaauagggacggucgggggcaucaguauucaauugucagaggugaaauuc
uuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuu
ucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccguc
guagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuu
aaugacccacucggcaccuuacgagaaaucaaagucuuuggguucugggg
ggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcacca
ccaggaguggagccugcggcuuaauuugacucaacacggggaaacucacc
agguccagacacaauaaggauugacagauugagagcucuuucuugauuuu
gugggugguggugcauggccguucuuaguugguggagugauuugucugcu
uaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagca
uuugcugguuauccacuucuuagagggacuaucgguuucaagccgaugga
aguuugaggcaauaacaggucugugaugcccuuagacguucugggccgca
cgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucu
ugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuau
ugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguug
auuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaa
uggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucau
uuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaa
ggaucau

...<<<<<...[[[[>>>>>[[[[.((((((................[[[
.[[[..<<....<<....<<..........>>...>>.>>......{{..
......[[[..{{..{{....[[[..................<.....<<
.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>
>>>[...((((((......<<<<<<<<<<......>>....<<......>
>)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}
}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>..
....>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<.......
...>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<
.....>>>..>>>...............<<.<<....<..........>.
...>>..>>......<<..<...........>..>>.........<<<<<
((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))
]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<
<..>>>>.>>>>>>....<<<<<..>>>>>...<<<<<.<<.......<<
...<.......>..<<<.....>>>....>>......>>.>>..>>>...
.......[[..((((((((....>>>>>>>>.)))))))).]]......]
]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>
......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>
>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>
...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<....
.>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<
<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<
<.<<<<<<..<<<.<<<<<<......<<........>>..........<<
<<<.<....<<<<<........<<.<<<........>>>.>>......>>
>>>...<<.<<<..<<.<<<<<<....<<<.<<.<......>....<<<.
.....>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<.
...>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>...
....>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.
>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>.
.>>....>>.......>>>>>>>......<....<<<<<<..........
>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>.
.....>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<
<<<<<.<<<..<.<<..<...<<<.>>>...>..>>.>..>>>.>>>>>>
>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>
.......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6s47 A role for the Saccharomyces cerevisiae ABCF protein New1 in translation termination/recycling.
• Resolution: 3.28 Å
• Binding residue (original residue number in PDB): R247 G248 S249 K251
• Binding residue (residue number reindexed from 1): R246 G247 S248 K250

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0042273 ribosomal large subunit biogenesis
• GO:1990145 maintenance of translational fidelity

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6s47, PDBe:6s47, PDBj:6s47
• PDBsum: 6s47
• PubMed: 31299085
• UniProt: P0CX45|RL2A_YEAST Large ribosomal subunit protein uL2A (Gene Name=RPL2A)