Structure of PDB 6p5k Chain AD Binding Site BS02

Receptor Information
>6p5k Chain AD (length=293) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMI
VRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTG
LLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLAR
TTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQ
NVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPV
YEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAA
Ligand information
>6p5k Chain 7 (length=119) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaa
gcuaagcagggucgggccugguuaguacuuggaugggagaccgccuggga
auaccgggugcuguaggcu
<<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..
>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>..
..>>>>>>>>>>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6p5k The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K8 K10 F13 K14 Y16 V18 F20 R21 R22 R24 K27 T28 Y30 R33 R50 I52 R54 T56 N57 R58 I61 Q63 E70 G71 D72 M73 I74 N94 Y95 A151 R152 T154 T155 G156 N157 K158 N203 V204 Y207 Q222 F223 S224 Q225 Y253 K255 K256 V261 W266 N267 R268 P269 K270 M271 L273 K276 R279 V280
Binding residue
(residue number reindexed from 1)		K6 K8 F11 K12 Y14 V16 F18 R19 R20 R22 K25 T26 Y28 R31 R48 I50 R52 T54 N55 R56 I59 Q61 E68 G69 D70 M71 I72 N92 Y93 A149 R150 T152 T153 G154 N155 K156 N201 V202 Y205 Q220 F221 S222 Q223 Y251 K253 K254 V259 W264 N265 R266 P267 K268 M269 L271 K274 R277 V278
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0008097 5S rRNA binding
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6p5k, PDBe:6p5k, PDBj:6p5k
PDBsum6p5k
PubMed31609474
UniProtP19949|RL5_RABIT Large ribosomal subunit protein uL18 (Gene Name=RPL5)

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