Structure of PDB 7o81 Chain AC Binding Site BS02

Receptor Information

>7o81 Chain AC (length=74) Species: 9986 (Oryctolagus cuniculus)

KKRKKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECG
AGVFMASHFDRHYCGKCCLTYCFN

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7o81 Chain AC Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7o81 Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): C121 C141
• Binding residue (residue number reindexed from 1): C44 C64
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0031386 protein tag activity
• GO:0031625 ubiquitin protein ligase binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation
• GO:0016567 protein ubiquitination
• GO:0019941 modification-dependent protein catabolic process

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7o81, PDBe:7o81, PDBj:7o81
• PDBsum: 7o81
• PubMed: 34029205
• UniProt: G1SK22|RS27A_RABIT Ubiquitin-ribosomal protein eS31 fusion protein (Gene Name=RPS27A)