Structure of PDB 6b4v Chain AC Binding Site BS02

Receptor Information

>6b4v Chain AC (length=189) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MEYRLKAYYREGEKPSALRRAGKLPGVMYNRHLNRKVYVDLVEFDKVFRQ
ASIHHVIVLELPDGQSLPTLVRQVNLDKRRRRPEHVDFFVLSDEPVEMYV
PLRFVGTPAGVRAGGVLQEIHRDILVKVSPRNIPEFIEVDVSGLEIGDSL
HASDLKLPPGVELAVSPEETIAAVVPPEDVEKLAEEAAA

Ligand information

>6b4v Chain GB (length=120) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacg
gaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccuggga
gaguaggucggugcggggga

<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>
>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>..
.....>>>.>>>>>>>>>>>

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6b4v Mechanism of Inhibition of Translation Termination by Blasticidin S.
Resolution	3.4 Å
Binding residue (original residue number in PDB)	R10 R19 Y29 N30 N34 R72 Q73 R79 E84 H85 D87 F89
Binding residue (residue number reindexed from 1)	R10 R19 Y29 N30 N34 R72 Q73 R79 E84 H85 D87 F89

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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External links

PDB	RCSB:6b4v, PDBe:6b4v, PDBj:6b4v
PDBsum	6b4v
PubMed	29366636
UniProt	Q72IA7\|RL25_THET2 Large ribosomal subunit protein bL25 (Gene Name=rplY)

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