Structure of PDB 7qi6 Chain AB Binding Site BS02

Receptor Information

>7qi6 Chain AB (length=225) Species: 9606 (Homo sapiens)

EDSTDFNDKILNEPLKHSDFFNVKELFSVRSLFDARVHLGHKAGCRHRFM
EPYIFGSRLDHDIIDLEQTATHLQLALNFTAHMAYRKGIILFISRNRQFS
YLIENMARDCGEYAHTRYFRGGMLTNARLLFGPTVRLPDLIIFLHTLNNI
FEPHVAVRDAAKMNIPTVGIVDTNCNPCLITYPVPGNDDSPLAVHLYCRL
FQTAITRAKEKRQQVEALYRLQGQK

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7qi6 Chain AB Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qi6 Structure of mitoribosome reveals mechanism of mRNA binding, tRNA interactions with L1 stalk, roles of cofactors and rRNA modifications.
• Resolution: 2.98 Å
• Binding residue (original residue number in PDB): H93 D224 D240 D241
• Binding residue (residue number reindexed from 1): H41 D172 D188 D189
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation
• GO:0061668 mitochondrial ribosome assembly

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005759 mitochondrial matrix
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7qi6, PDBe:7qi6, PDBj:7qi6
• PDBsum: 7qi6
• PubMed: 38769321
• UniProt: Q9Y399|RT02_HUMAN Small ribosomal subunit protein uS2m (Gene Name=MRPS2)