Structure of PDB 8dwb Chain AAA Binding Site BS02

Receptor Information

>8dwb Chain AAA (length=388) Species: 480019 (Influenza A virus (A/Moscow/10/1999(H3N2)))

AEYRNWSKPQCNITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPDKCYQ
FALGQGTTLNNGHSNDTVHDRTPYRTLLMNELGVPFHLGTKQVCIAWSSS
SCHDGKAWLHVCVTGDDENATASFIYNGRLVDSIGSWSKKILRTQESECV
CINGTCTVVMTDGSASGKADTKILFIEEGKIVHTSPLSGSAQHVEECSCY
PRYPGVRCVCRDNWKGSNRPIVDINVKDYSIVSSYVCSGLVGDTPRKNDS
SSSSHCLDPNNEEGGHGVKGWAFDDGNDVWMGRTISEKLRSGYETFKVIE
GWSKPNSKLQINRQVIVDRGNRSGYSGIFSVEGKSCINRCFYVELIRGRK
QETEVLWTSNSIVVFCGTSGTYGTGSWPDGADINLMPI

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 8dwb Chain AAA Residue 806

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8dwb Mutational fitness landscape of human influenza H3N2 neuraminidase.
• Resolution: 1.602 Å
• Binding residue (original residue number in PDB): D293 G297 D324 G345 H347
• Binding residue (residue number reindexed from 1): D212 G216 D243 G264 H266
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0046761 viral budding from plasma membrane

Cellular Component

• GO:0016020 membrane
• GO:0033644 host cell membrane
• GO:0055036 virion membrane

External links

• PDB: RCSB:8dwb, PDBe:8dwb, PDBj:8dwb
• PDBsum: 8dwb
• PubMed: 36640354
• UniProt: Q8AZ87