Structure of PDB 7z4o Chain AAA Binding Site BS02

Receptor Information
>7z4o Chain AAA (length=514) Species: 11320 (Influenza A virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKE
VNARIEPFLRTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGI
PLYDAIKCMKTFFGWKEPNIIKPHEKGINPNYLLTWKQVLAELQDIENEE
KIPRTKNMKKTSQLKWALGENMAPEKVDFEDCKDVNDLKQYDSDEPEPRS
LACWIQSEFNKACELTDSSWVELDEIGEDVAPIEHIASMRRNYFTAEVSH
CRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYG
FIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRT
AVGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSV
KEKDLTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYAS
PQLEGFSAESRKLLLIVQALRDNLEPGTFDLEGLYEAIEECLINDPWVLL
NASWFNSFLTHALR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7z4o Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Resolution3.412 Å
Binding residue
(original residue number in PDB)		H326 K328 W368 G371 N373 M374 A375 P376 Y393 S395 P398 R508 H510 R512 V517 N519 K539 R566 T567 N568 G569 K574
Binding residue
(residue number reindexed from 1)		H124 K126 W166 G169 N171 M172 A173 P174 Y191 S193 P196 R306 H308 R310 V315 N317 K337 R364 T365 N366 G367 K372
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7z4o, PDBe:7z4o, PDBj:7z4o
PDBsum7z4o
PubMed35605026
UniProtM9TI86

[Back to BioLiP]