Structure of PDB 7qf9 Chain AAA Binding Site BS02

Receptor Information
>7qf9 Chain AAA (length=147) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKI
LKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTN
TWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
Ligand information
Ligand IDFAR
InChIInChI=1S/C15H26/c1-6-14(4)10-8-12-15(5)11-7-9-13(2)3/h6,9,12H,7-8,10-11H2,1-5H3/b14-6+,15-12+
InChIKeyJXBSHSBNOVLGHF-BUJBXKITSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CC=C(C)CCC=C(C)CCC=C(C)C
OpenEye OEToolkits 1.5.0C\C=C(/C)\CC\C=C(/C)\CCC=C(C)C
CACTVS 3.341C\C=C(C)\CC\C=C(C)\CCC=C(C)C
ACDLabs 10.04C(=C/C)(\CC/C=C(/CC/C=C(\C)C)C)C
FormulaC15 H26
NameFARNESYL
ChEMBL
DrugBank
ZINC
PDB chain7qf9 Chain EEE Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7qf9 Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		M20 Q78 I129 L147
Binding residue
(residue number reindexed from 1)		M17 Q75 I126 L144
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0031267 small GTPase binding
Biological Process
GO:0007601 visual perception
GO:0050953 sensory perception of light stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7qf9, PDBe:7qf9, PDBj:7qf9
PDBsum7qf9
PubMed35104933
UniProtO43924|PDE6D_HUMAN Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (Gene Name=PDE6D)

[Back to BioLiP]