Structure of PDB 6tt5 Chain AAA Binding Site BS02

Receptor Information

>6tt5 Chain AAA (length=348) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLE
CSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDESGEK
EEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHSG
GRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVVW
LNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRNTQI
HACRHKLPCGITSRNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYR
ACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCRS

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

6tt5 Chain AAA Residue 408 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	6tt5 Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
Resolution	1.5 Å
Binding residue (original residue number in PDB)	H38 D136
Binding residue (residue number reindexed from 1)	H36 D133
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.1.-.-

External links

PDB	RCSB:6tt5, PDBe:6tt5, PDBj:6tt5
PDBsum	6tt5
PubMed	34387696
UniProt	Q96SD1\|DCR1C_HUMAN Protein artemis (Gene Name=DCLRE1C)

[Back to BioLiP]