Structure of PDB 6tsx Chain AAA Binding Site BS02

Receptor Information

>6tsx Chain AAA (length=169) Species: 9796 (Equus caballus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QIRQNYSTEVEAAVNRLVNLYLRASYTYLSLGFYFDRDDVALEGVCHFFR
ELAEEKREGAERLLKMQNQRGGRALFQDLQKPSQDEWGTTLDAMKAAIVL
EKSLNQALLDLHALGSAQADPHLCDFLESHFLDEEVKLIKKMGDHLTNIQ
RLVGSQAGLGEYLFERLTL

Ligand information

Ligand ID

InChI

InChI=1S/Fe/q+3

InChIKey

VTLYFUHAOXGGBS-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	[Fe+3]

Formula

Name

FE (III) ION

PDB chain

6tsx Chain AAA Residue 205 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6tsx Iron Biomineral Growth from the Initial Nucleation Seed in L-Ferritin.
Resolution	2.021 Å
Binding residue (original residue number in PDB)	E56 E60
Binding residue (residue number reindexed from 1)	E54 E58
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005506	iron ion binding
GO:0008198	ferrous iron binding
GO:0008199	ferric iron binding
GO:0046872	metal ion binding

	Biological Process
GO:0006826	iron ion transport
GO:0006879	intracellular iron ion homeostasis
GO:0006880	intracellular sequestering of iron ion

	Cellular Component
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005776	autophagosome
GO:0031410	cytoplasmic vesicle
GO:0044754	autolysosome
GO:0070288	ferritin complex

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Cellular Component

External links

PDB	RCSB:6tsx, PDBe:6tsx, PDBj:6tsx
PDBsum	6tsx
PubMed	32027764
UniProt	P02791\|FRIL_HORSE Ferritin light chain (Gene Name=FTL)

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