Structure of PDB 8ipa Chain AA Binding Site BS02

Receptor Information

>8ipa Chain AA (length=229) Species: 4565 (Triticum aestivum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NPLFEKRPKQFGIGGALPPKKDLHRFVKWPKVVRIQRQRRILKQRLKVPP
ALHQFTRTLDKNLATNLFKMLLKYRPEDKAAKKERLLKRAQAEAEGKTVE
AKKPIVVKYGLNHVTYLIEQSKAQLVVIAHDVDPIELVVWLPALCRKMEV
PYCIVKGKSRLGSIVHKKTASVLCLTTVKNEDKLEFSKILEAIKANFNDK
FDEVRKKWGGGVMGSKSQAKTKARERLIA

Ligand information

>8ipa Chain SB (length=160) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cgacucucggcaacggauaucucggcucucgcaucgaugaagaacguagc
gaaaugcgauaccuggugugaauugcagaaucccgugaaccaucgagucu
uugaacgcaaguugcgcccgaggccauccggccgagggcacgccugccug
ggcgucacgc

.........................................<<<<<<.((
.....>>>....<<<<<<<.....))............>.>>>>.>>..>
>>....<<.....>><<<<..<<<<....>>>>..>>>>...........
..........

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8ipa Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1.
Resolution	3.4 Å
Binding residue (original residue number in PDB)	W50 V54 Q57 R58 R61 K82 H151 K177 R181
Binding residue (residue number reindexed from 1)	W29 V33 Q36 R37 R40 K61 H130 K156 R160

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003723	RNA binding

	Biological Process
GO:0000470	maturation of LSU-rRNA
GO:0042254	ribosome biogenesis

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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External links

PDB	RCSB:8ipa, PDBe:8ipa, PDBj:8ipa
PDBsum	8ipa
PubMed	38267667
UniProt	A0A3B6RED0

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