Structure of PDB 7tbm Chain A5 Binding Site BS02

Receptor Information

>7tbm Chain A5 (length=1276) Species: 9606 (Homo sapiens)

DLPPVAKAAQVVNQTLQLDDSYPDLDSYCRPGASSDYEMQSSDSSWAPFH
VVRHHNIPDKVFEHLNAGEVFTKLGLFAEIGYAWASIDSSLFLWDYTHPN
PELIGYEEATHTITAVALVPPKPGVFVKTITHVLVVATTSEIILLGVSAT
PTPSGSKSLTLYSTRMSVHRGGSDVSFIVGTKDGRIFLGGESDTDIHEIF
YQQEERWFSSRCGKINHSHPFGSRQQEWLRGLYVDDTRNLLYSLSNRSTI
RTYHMEGPEKLTKVIEKDKTSCLRDFAHMADSSPLFTDKTNIVALSPIPA
TEASKLHLMALTDTGCRLFLSATSSASYTALAPQSMQLQFVKFPPRESPT
RIRTLSQLDKTSRALDPSALGFRFSPGYFFDVVRKHPNQDMLFVSAPDTG
RIKVTQPASALKYFEQGTWIELENGNRTIEIGLTTAPFAAAKQPLGFGNE
LAVQFDQVPGEFAVLTNTGVHIVRRRRLVDIFAKALGNCVSASDDALERE
VRKFINQYGRVETIAAALAVACGQGSDLMDRNTENLARAAFIEYGGQPRL
ASVRLSSRHDALALYLTRLVRTLWKAKVVQVDISSTIPTSKLVTIQENVE
RLRNFLEANKSTIQGLAPPDIANQKEHQALHALQKLMESISEGISFVLML
FDERVSDIYARLDAVSQQQLKDLTYEQLFSQTPGKELAKVLVKAIVNRNI
ASGANVETVADALRRRCGSFCSPDDVVTFKAQEQLQRASEQAHNSPVLRA
LLAESLRLFEQVAGSLTPANLTTAVEQMISLKYYAGAIQLCLTVAQQKDR
GNTALSWVNDGKPANDSRKKAFDERKICYNLIHQVLDKLESDFAGEPELV
DGRPTLAATKRMEAYNVVNDSSDEVFHFDMYEWYIEKGWTDRILSIDSPH
VITYLQRLAETDFRHAELLCRFYTTRSRFFEAAQVQTNLAKSDLNISLKD
RIILLSRAKGNASVNTIGISRQQQQQLNHEASELLEIAHIQDDLLERLVA
DPRIPEERKAEIEEFLDGPIRTLTDLFNDYADQANYYDLCLLIFHAADFH
NPRTIMDTWNNLINQSHFEAEQRREYWEIVQAGGDLPAGVIAEPPLPYVY
VSQQIQLIAHRTSLDSLIFPVNSLLPVVCAYAINNGQDASIGADPCWPIQ
LFLNLGVPHALMVQVLENVLDTQEAPFTGRRRKLVVQWIAMAVDMWVREV
ERRGAMAAAVMGSWVSELLGRADQVLTQIAGTGATLRGGAASDAEEIASL
RRTVKGLKRSVDMLLGGEMARMSFFR

Ligand information

>7tbm Chain C2 (length=19) Species: 9606 (Homo sapiens)

HKKLVINKDMRTDLFSPPN

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7tbm Architecture of the cytoplasmic face of the nuclear pore.
• Resolution: 37.0 Å
• Binding residue (original residue number in PDB): F144 K146 L147 F150 I153 Y155 A156 W157 A158 S159 I160 D161 S162 S163 L164 F165 L166 H171 P172 N173 E175 I177 G178 Y179 E180 I186 T187 A188 V189 A190 L191 V209 G219 V220 S221 A222 S231 L232 T233 L234 Y235 S249
• Binding residue (residue number reindexed from 1): F71 K73 L74 F77 I80 Y82 A83 W84 A85 S86 I87 D88 S89 S90 L91 F92 L93 H98 P99 N100 E102 I104 G105 Y106 E107 I113 T114 A115 V116 A117 L118 V136 G146 V147 S148 A149 S158 L159 T160 L161 Y162 S176

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Mon Nov 25 20:41:54 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1435     title=pdb2title(pdbid)

   1436     if bs.startswith("BS"):

=> 1437         pubmed,uniprot=display_interaction(pdbid,asym_id,bs,title)

   1438     else:

   1439         if lig3:

pubmed = '', uniprot = '', display_interaction = <function display_interaction>, pdbid = '7tbm', asym_id = 'A5', bs = 'BS02', title = 'Architecture of the cytoplasmic face of the nuclear pore.'

 /var/www/html/BioLiP/pdb.cgi in display_interaction(pdbid='7tbm', asym_id='A5', bs='BS02', title='Architecture of the cytoplasmic face of the nuclear pore.')

   1295         display_ec(ec,csaOrig,csaRenu)

   1296     if go:

=> 1297         display_go(go,uniprot,pdbid,asym_id)

   1298     return pubmed,uniprot

   1299 

global display_go = <function display_go>, go = '0005643,0006913,0017056', uniprot = '', pdbid = '7tbm', asym_id = 'A5'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005643,0006913,0017056', uniprot='', pdbid='7tbm', asym_id='A5')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>