Structure of PDB 7tbl Chain A5 Binding Site BS02

Receptor Information

>7tbl Chain A5 (length=1276) Species: 9606 (Homo sapiens)

DLPPVAKAAQVVNQTLQLDDSYPDLDSYCRPGASSDYEMQSSDSSWAPFH
VVRHHNIPDKVFEHLNAGEVFTKLGLFAEIGYAWASIDSSLFLWDYTHPN
PELIGYEEATHTITAVALVPPKPGVFVKTITHVLVVATTSEIILLGVSAT
PTPSGSKSLTLYSTRMSVHRGGSDVSFIVGTKDGRIFLGGESDTDIHEIF
YQQEERWFSSRCGKINHSHPFGSRQQEWLRGLYVDDTRNLLYSLSNRSTI
RTYHMEGPEKLTKVIEKDKTSCLRDFAHMADSSPLFTDKTNIVALSPIPA
TEASKLHLMALTDTGCRLFLSATSSASYTALAPQSMQLQFVKFPPRESPT
RIRTLSQLDKTSRALDPSALGFRFSPGYFFDVVRKHPNQDMLFVSAPDTG
RIKVTQPASALKYFEQGTWIELENGNRTIEIGLTTAPFAAAKQPLGFGNE
LAVQFDQVPGEFAVLTNTGVHIVRRRRLVDIFAKALGNCVSASDDALERE
VRKFINQYGRVETIAAALAVACGQGSDLMDRNTENLARAAFIEYGGQPRL
ASVRLSSRHDALALYLTRLVRTLWKAKVVQVDISSTIPTSKLVTIQENVE
RLRNFLEANKSTIQGLAPPDIANQKEHQALHALQKLMESISEGISFVLML
FDERVSDIYARLDAVSQQQLKDLTYEQLFSQTPGKELAKVLVKAIVNRNI
ASGANVETVADALRRRCGSFCSPDDVVTFKAQEQLQRASEQAHNSPVLRA
LLAESLRLFEQVAGSLTPANLTTAVEQMISLKYYAGAIQLCLTVAQQKDR
GNTALSWVNDGKPANDSRKKAFDERKICYNLIHQVLDKLESDFAGEPELV
DGRPTLAATKRMEAYNVVNDSSDEVFHFDMYEWYIEKGWTDRILSIDSPH
VITYLQRLAETDFRHAELLCRFYTTRSRFFEAAQVQTNLAKSDLNISLKD
RIILLSRAKGNASVNTIGISRQQQQQLNHEASELLEIAHIQDDLLERLVA
DPRIPEERKAEIEEFLDGPIRTLTDLFNDYADQANYYDLCLLIFHAADFH
NPRTIMDTWNNLINQSHFEAEQRREYWEIVQDLPDLPIAVIAEPPLPYVY
VSQQIQLIAHRTSLDSLIFPVNSLLPVVCAYAINNGQDASIGADPCWPIQ
LFLNLGVPHALMVQVLENVLDTQEAPFTGRRRKLVVQWIAMAVDMWVREV
ERRASMSEAVMGSWVSELLGRADQVLTQIAGTGATLRGGAASDAEEIASL
RRTVKGLKRSVDMLLGGEMARMSFFR

Ligand information

>7tbl Chain C2 (length=19) Species: 9606 (Homo sapiens)

HKKLVINKDMRTDLFSPPN

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7tbl Architecture of the cytoplasmic face of the nuclear pore.
• Resolution: 23.0 Å
• Binding residue (original residue number in PDB): L147 G148 L149 F150 I153 G154 Y155 A156 W157 L164 F165 L166 W167 P172 I177 G178 Y179 E180 A188 V189 A190 L207 V209 S221 A222 T223 P224 T225 S227 G228 S229 K230 S231 L232 T233 E527
• Binding residue (residue number reindexed from 1): L74 G75 L76 F77 I80 G81 Y82 A83 W84 L91 F92 L93 W94 P99 I104 G105 Y106 E107 A115 V116 A117 L134 V136 S148 A149 T150 P151 T152 S154 G155 S156 K157 S158 L159 T160 E430

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Tue Nov 26 14:07:43 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1435     title=pdb2title(pdbid)

   1436     if bs.startswith("BS"):

=> 1437         pubmed,uniprot=display_interaction(pdbid,asym_id,bs,title)

   1438     else:

   1439         if lig3:

pubmed = '', uniprot = '', display_interaction = <function display_interaction>, pdbid = '7tbl', asym_id = 'A5', bs = 'BS02', title = 'Architecture of the cytoplasmic face of the nuclear pore.'

 /var/www/html/BioLiP/pdb.cgi in display_interaction(pdbid='7tbl', asym_id='A5', bs='BS02', title='Architecture of the cytoplasmic face of the nuclear pore.')

   1295         display_ec(ec,csaOrig,csaRenu)

   1296     if go:

=> 1297         display_go(go,uniprot,pdbid,asym_id)

   1298     return pubmed,uniprot

   1299 

global display_go = <function display_go>, go = '0005643,0006913,0017056', uniprot = '', pdbid = '7tbl', asym_id = 'A5'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005643,0006913,0017056', uniprot='', pdbid='7tbl', asym_id='A5')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>