Structure of PDB 9f6e Chain A Binding Site BS02

Receptor Information

>9f6e Chain A (length=1140) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SSVSALKRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDK
RLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFLSKKFQG
KIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKK
NREQDDQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEI
TRRDDLVERPDPVVLAFAIATTKLPLKFPDAETDQIMMISYMIDGQGYLI
TNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPT
IMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDC
LRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLAT
YSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMV
QAFHANIIFPNKQEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIP
CRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVCDEIKSKL
ASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFN
KPGANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAF
HELSREEQAKYEKRRLADYCRKAYKKIHITKVEERLTTICQRENSFYVDT
VRAFRDRRYEFKGLHKVWKKKLSAAVEVGDAAEVKRCKNMEVLYDSLQLA
HKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPL
ELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIMVKEGFTN
DQYQELAEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYA
VFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVA
KVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTA
KRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRK
HFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNP
VPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTM

Ligand information

>9f6e Chain T (length=28) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gaattggtgagggttgggaagtggaagg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	9f6e Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon.
Resolution	3.74 Å
Binding residue (original residue number in PDB)	G498 Y539 V540 G541 G542 R672 K732 G817 M820 R821 K953 R955 R975 P1088 V1089 T1090 Y1132 R1136 K1143
Binding residue (residue number reindexed from 1)	G441 Y482 V483 G484 G485 R615 K675 G760 M763 R764 K896 R898 R918 P1031 V1032 T1033 Y1075 R1079 K1086

External links

PDB	RCSB:9f6e, PDBe:9f6e, PDBj:9f6e
PDBsum	9f6e
PubMed	39112807
UniProt	Q07864\|DPOE1_HUMAN DNA polymerase epsilon catalytic subunit A (Gene Name=POLE)

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