Structure of PDB 9ci9 Chain A Binding Site BS02

Receptor Information

>9ci9 Chain A (length=424) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVS
YEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVME
IMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLP
QGVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERET
GFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSL
GGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHD
PVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRND
NDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNT
SGIQTEWSPPLTMLFLCATKFSAS

Ligand information

>9ci9 Chain P (length=8) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

agcgtcaa

Receptor-Ligand Complex Structure

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Structure summary

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PDB	9ci9 DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta.
Resolution	2.09 Å
Binding residue (original residue number in PDB)	S113 E116 K224 S257 G259 K261 L262 R377 R382 R383
Binding residue (residue number reindexed from 1)	S112 E115 K216 S249 G251 K253 L254 R369 R374 R375

External links

PDB	RCSB:9ci9, PDBe:9ci9, PDBj:9ci9
PDBsum	9ci9
PubMed	39259676
UniProt	Q9Y253\|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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