Structure of PDB 8zng Chain A Binding Site BS02

Receptor Information
>8zng Chain A (length=416) Species: 49899 (Thermococcus profundus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IDPFEMAVKQLERAAQYMDISEEALEWLKKPMRIVEVSVPIEMDDGSVKV
FTGFRVQHNWARGPTKGGIRWHPAETLSTVKALATFMTWKVAVVDLPYGG
GKGGIIVNPKELSEREQERLARAYIRAVYDVIGPWTDIPAPDVYTNPKIM
GWMMDEYETIMRRKGPAFGVITGKPLSIGGSLGRGTATAQGAIFTIREAA
KALGIDLKGKKIAVQGYGNAGYYTAKLAKEQLGMTVVAVSDSRGGIYNPD
GLDPDEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITE
KNADNIKAKIVAEVANGPVTPEADDILREKGILQIPDFLCNAGGVTVSYF
EWVQNINGYYWTEEEVREKLDKKMTKAFWEVYNTHKDKNIHMRDAAYVVA
VSRVYQAMKDRGWVKK
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain8zng Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8zng Mechanism for drastic reduction in catalytic activity of Trp89Phe-mutated glutamate dehydrogenase revealed by crystal structure and cryoEM-sampling of metastable conformation in action
Resolution2.5 Å
Binding residue
(original residue number in PDB)		K69 K93 A143 S351
Binding residue
(residue number reindexed from 1)		K66 K90 A140 S348
Annotation score5
Enzymatic activity
Enzyme Commision number 1.4.1.3: glutamate dehydrogenase [NAD(P)(+)].
Gene Ontology
Molecular Function
GO:0004352 glutamate dehydrogenase (NAD+) activity
GO:0004353 glutamate dehydrogenase [NAD(P)+] activity
GO:0004354 glutamate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006538 glutamate catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8zng, PDBe:8zng, PDBj:8zng
PDBsum8zng
PubMed
UniProtO74024|DHE3_THEPR Glutamate dehydrogenase (Gene Name=gdhA)

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