Structure of PDB 8yxp Chain A Binding Site BS02

Receptor Information
>8yxp Chain A (length=1350) Species: 2560602 (Mumps orthorubulavirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LNEILLPEVHLNSPIVRYKLFYYILHGQLPNDLEPDDLGPLANQNWKAIR
AEESQVHARLKQIRVELIARIPSLRWTRSQREIAILIWPRILPILQAYDL
RQSMQLPTVWEKLTQSTVNLISDGLERVVLHISNQLTGKPNLFTRSRAYS
IPSTRELSQIWFNNEWSGSVKTWLMIKYRMRQLITNQKTGELTDLVTIVD
TRSTLCIITPELVALYSSEHKALTYLTFEMVLMVTDMLEGRLNVSSLCTA
SHYLSPLKKRIEVLLTLVDDLALLMGDKVYGIVSSLESFVYAQLQYGDPV
IDIKGTFYGFICNEILDLLTEDNIFTEEEANKVLLDLTSQFDNLSPDLTA
ELLCIMRLWGHPTLTASQAASKVRESMCAPKVLDFQTIMKTLAFFHAILI
NGYRRSHNGIWPPTTLHGNAPKSLIEMRHDNSELKYEYVLKNWKSISMLR
IHKCFDASPDEDLSIFMKDKAISCPRQDWMGVFRRSLIKQRYRDANRPLP
QPFNRRLLLNFLEDDRFDPIKELEYVTSGEYLRDPEFCASYSLKEKEIKA
TGRIFAKMTKRMRSCQVIAESLLANHAGKLMRENGVVLDQLKLTKSLLTM
NQIGIISEHGFEIAACFLTTDLTKYCLNWRYQVIIPFARTLNSMYGIPHL
FEWIHLRLMRSTLYVGDPFNPPSDPTQLDLDTALNDDIFIVSPRGGIEGL
CQKLWTMISISTIILSATEANTRVMSMVQGDNQAIAITTRVVRSLSHSEK
KEQAYKASKLFFERLRANNHGIGHHLKEQETILSSDFFIYSKRVFYKGRI
LTQALKNVSKMCLTADILGDCSQASCSNLATTVMRLTENGVEKDLCYFLN
AFMTIRQLCYDLVFPQTKSLSQDITNAYLNHPILISRLCLLPSQLGGLNF
LSCSRLFNRNIGDPLVSAIADVKRLIKAGCLDIWVLYNILGRRPGKGKWS
TLAADPYTLNIDYLVPSTTFLKKHAQYTLMERSVNPMLRGVFSENAAEEE
EELAQYLLDREVVMPRVAHVILAQSSCGRRKQIQGYLDSTRTIIRYSLEV
RPLSAKKLNTVIEYNLLYLSYNLEIIEKPNIVQPFLNAINVDTCSIDIAR
SLRKLSWATLLNGRPIEGLETPDPIELVHGCLIIGSDECEHCSSGDDKFT
WFFLPKGIRLDDDPASNPPIRVPYIGSKTDVASMAYIKGASVSLKSALRL
AGVYIWAFGDTEESWQDAYELASTRVNLTLEQLQSLTPLPTSANLVHRKF
TPASSYAFSSFVHISNDCQILTDSNLIYQQVMITGLALIETWNNPPINFS
VYETTLHLHTGSSCCIRPVESCVVNPPLLPVPLINVPQMNKFVYDPEPLS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8yxp Chain A Residue 3002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8yxp Structures of the mumps virus polymerase complex via cryo-electron microscopy.
Resolution3.01 Å
Binding residue
(original residue number in PDB)		C1379 C1380
Binding residue
(residue number reindexed from 1)		C1314 C1315
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.375: NNS virus cap methyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.88: GDP polyribonucleotidyltransferase.
3.6.1.-
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
GO:0016787 hydrolase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006370 7-methylguanosine mRNA capping
GO:0032259 methylation
GO:0106005 RNA 5'-cap (guanine-N7)-methylation
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8yxp, PDBe:8yxp, PDBj:8yxp
PDBsum8yxp
PubMed38760379
UniProtC0JJA4

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