Structure of PDB 8yrs Chain A Binding Site BS02

Receptor Information

>8yrs Chain A (length=530) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DSSPAAWNKEDFPWSGKVKDILQNVFKLEKFRPLQLETINVTMAGKEVFL
VMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATML
NASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAKSKMFMSRLEKAYEAR
RFTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIGLTATATNHV
LTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNTEDFIEDIVKLINGR
YKGQSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWS
ANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMK
ADCILYYGFGDIFRISSMVVMENVGQQKLYEMVSYCQNISKCRRVLMAQH
FDEVWNSEACNKMCDNCCKSAFERKNITEYCRDLIKILKQAEELNEKLTP
LKLIDSWMGKGAAKLRVAGVVAPTLPREDLEKIIAHFLIQQYLKEDYSFT
AYATISYLKIGPKANLLNNEAHAITMQVTK

Ligand information

>8yrs Chain Q (length=19) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tggatctcgacgctctccc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8yrs Crystal structure of human RECQ1 helicase containing a flexible linker in complex with tailed duplex DNA
Resolution	2.43 Å
Binding residue (original residue number in PDB)	F322 Q324 H345 A346 V372 A373 R425 M429 T572 Y574 A575
Binding residue (residue number reindexed from 1)	F261 Q263 H284 A285 V311 A312 R364 M368 T500 Y502 A503

External links

PDB	RCSB:8yrs, PDBe:8yrs, PDBj:8yrs
PDBsum	8yrs
PubMed
UniProt	P46063\|RECQ1_HUMAN ATP-dependent DNA helicase Q1 (Gene Name=RECQL)

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