Structure of PDB 8xn8 Chain A Binding Site BS02

Receptor Information

>8xn8 Chain A (length=450) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYI
PSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKG
AYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSK
HADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVW
MGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE
PIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNY
VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPE
AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP
CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGEN

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

8xn8 Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8xn8 The Crystal Structure of SRC from Biortus.
Resolution	1.95 Å
Binding residue (original residue number in PDB)	N393 D406
Binding residue (residue number reindexed from 1)	N309 D322
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.7.10.2: non-specific protein-tyrosine kinase.

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:8xn8, PDBe:8xn8, PDBj:8xn8
PDBsum	8xn8
PubMed
UniProt	P05480\|SRC_MOUSE Proto-oncogene tyrosine-protein kinase Src (Gene Name=Src)

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