Structure of PDB 8xcp Chain A Binding Site BS02

Receptor Information
>8xcp Chain A (length=415) Species: 49899 (Thermococcus profundus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPFEMAVKQLERAAQYMDISEEALEWLKKPMRIVEVSVPIEMDDGSVKVF
TGFRVQHNWARGPTKGGIRWHPAETLSTVKALATWMTWKVAVVDLPYGGG
KGGIIVNPKELSEREQERLARAYIRAVYDVIGPWTDIPAPDVYTNPKIMG
WMMDEYETIMRRKGPAFGVITGKPLSIGGSLGRGTATAQGAIFTIREAAK
ALGIDLKGKKIAVQGYGNAGYYTAKLAKEQLGMTVVAVSDSRGGIYNPDG
LDPDEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITEK
NADNIKAKIVAEVANGPVTPEADDILREKGILQIPDFLCNAGGVTVSYFE
WVQNINGYYWTEEEVREKLDKKMTKAFWEVYNTHKDKNIHMRDAAYVVAV
SRVYQAMKDRGWVKK
Ligand information
Ligand IDGGL
InChIInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKeyWHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.2C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.2C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370N[CH](CCC(O)=O)C(O)=O
FormulaC5 H9 N O4
NameGAMMA-L-GLUTAMIC ACID;
L-GLUTAMIC ACID
ChEMBLCHEMBL575060
DrugBankDB00142
ZINCZINC000001482113
PDB chain8xcp Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8xcp CryoEM-sampling of metastable conformations appearing in cofactor-ligand association and catalysis of glutamate dehydrogenase
Resolution2.64 Å
Binding residue
(original residue number in PDB)		K69 M90 A143 P144
Binding residue
(residue number reindexed from 1)		K65 M86 A139 P140
Annotation score5
Enzymatic activity
Enzyme Commision number 1.4.1.3: glutamate dehydrogenase [NAD(P)(+)].
Gene Ontology
Molecular Function
GO:0004352 glutamate dehydrogenase (NAD+) activity
GO:0004353 glutamate dehydrogenase [NAD(P)+] activity
GO:0004354 glutamate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
Biological Process
GO:0006520 amino acid metabolic process
GO:0006538 glutamate catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8xcp, PDBe:8xcp, PDBj:8xcp
PDBsum8xcp
PubMed38750092
UniProtO74024|DHE3_THEPR Glutamate dehydrogenase (Gene Name=gdhA)

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