Structure of PDB 8xc1 Chain A Binding Site BS02

Receptor Information
>8xc1 Chain A (length=660) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NSSVLVFEISSKMKMIEKKLEANTVHVLRLELDQSFILDLTKVAAEIVDS
SKYSKEDGVILEVTVSNGRDSFLLKLPTVYPNLKLYTDGKLLNPLVEQDF
GAHRKRHRIGDPHFHQNLIVTVQSRLNADIDYRLHVTHLDRAQYDFLKFK
TGQTTKTLSNQKLTFVKPIGFFLNCSEQNISQFHVTLYSEDDICANLITV
PANESIYDRSVISDKTHNRRVLSFTKRADIFFTETEISMFKSFRIFVFIA
PDDSGCSTNTSRKSFNEKKKISFEFKKLENQSYAVPTALMMIFLTTPCLL
FLPIVINIIKNSSLHGQMLQYPVAIILPVLMHTAIEFHKWTTSTMANRDE
MCFHNHACARPLGELRAWNNIITNIGYTLYGAIFIVLSICRRGSHVFGTY
ECTLLDVTIGVFMVLQSIASATYHICPSDVAFQFDTPCIQVICGLLMVRQ
WFVRHESPSPAYTNILLVGVVSLNFLISAFSKTSYVRFIIAVIHVIVVGS
ICLAKERSLGSEKLKTRFFIMAFSMGNFAAIVMYLTLSAFHLNQIATYCF
IINCIMYLMYYGCMKVLHSERITSKAKLCGALSLLAWAVAGFFFFQDDTD
WTRSAAASRALNKPCLLLGFFGSHDLWHIFGALAGLFTFIFVSFVDDDLI
NTRKTSINIF
Ligand information
>8xc1 Chain D (length=30) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccaagcgacuucugucaucccagcccgucc
..............................
Receptor-Ligand Complex Structure
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PDB8xc1 Structural basis for double-stranded RNA recognition by SID1.
Resolution2.21 Å
Binding residue
(original residue number in PDB)		K45 K136 R172 A173 N297 K299
Binding residue
(residue number reindexed from 1)		K14 K105 R141 A142 N266 K268
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0051033 RNA transmembrane transporter activity
Biological Process
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0033227 dsRNA transport
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0050658 RNA transport
Cellular Component
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xc1, PDBe:8xc1, PDBj:8xc1
PDBsum8xc1
PubMed38742627
UniProtQ9GZC8|SID1_CAEEL Systemic RNA interference defective protein 1 (Gene Name=sid-1)

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