Structure of PDB 8wpu Chain A Binding Site BS02

Receptor Information
>8wpu Chain A (length=803) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFR
WLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNK
IDSLNLDCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRL
LSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGI
EKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSG
PDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALK
AGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQRPLCTGDENISS
VETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIK
KVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSI
VFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKG
IIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEI
EFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYL
LLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVL
LVFEAKWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIF
ITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSML
IFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILF
KPS
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8wpu Chain A Residue 1108 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8wpu Structural insights into asymmetric activation of the calcium-sensing receptor-G q complex.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		S84 P85 A86 L87 L88 P89
Binding residue
(residue number reindexed from 1)		S65 P66 A67 L68 L69 P70
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wpu, PDBe:8wpu, PDBj:8wpu
PDBsum8wpu
PubMed37919470
UniProtP41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)

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