BioLiP

Receptor Information

>8wd8 Chain A (length=750) Species: 277988 (Thermococcus thioreducens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MLMKVLTNMVKLNQDIIPNEIYLYKIFNKPEDGMNIYKIAYRNHGIVIDP
QNRIIATPSELEYSGKFAIEDEISFNELPENYQNRLVLRILRDNGISDHA
LSRTLQKYRKPKPFGDFEVIPEIRSSVIKHGGDFYLVLHLSHQIRSKKTL
WELVGRNKDALRDFLKEHRGTILLRDIASEHKVVYKPIFKRYNGDPDLIE
DNSNDVEHWYDYHLERYWNTPELKKEFYKKFGPVDLNQPIILAKPLRQHN
RGDLVHLLPQFVVPVYNAEQLNDILASEILEYLKLTSNQRISLLSRLIND
IKTNTNIIVSSLTELEANTFDVDLNDMLQVRNADNVKVTLSELEISKTRL
FTWMKSRKYPVILPYDIPQKLKKIEKIPVFIIVDSALSRDIQTFAKDEFR
YLISSLQKSLSNWVDFPILDIRDKYIFTIDLTSDKDIVNLSIKLVNLMKN
AELGLALIATRTKLPNETFDEVKKRLFSVNIISQVVNEATLYKRDKYNES
RLNLYVQHNLLFQILSKLGIKYYVLRHKFSYDYIVGIDVTPMKLSHGYIG
GSAVMFDSQGYIRKIIPVEIGEQMGESIDMKEFFKDMVVQFGKFGIDLEG
KSILILRDGKITKDEEEGLAYISKVFGIKITTFNIVKRHLLRIFANRKLY
LRLANSVYLLPHRIKQSVGTPVPLKLSEKRLILDGTITSQEITYNDIFEI
LLLSELNYGSISADMKLPAPVHYAHKFVRALRKGWRIREELLAEGFLYFV

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8wd8 Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonaute.
Resolution	2.9 Å
Binding residue (original residue number in PDB)	Y37 D49 P50 Y82 S141 H142 Q143 R175 L246 R247 K284 R290 L464 F469 K473 V485 V486 T490 V506 N509 Q513 H546 E576 T612 K613 R642 T670 P671 G709 A713 M715 K716
Binding residue (residue number reindexed from 1)	Y37 D49 P50 Y82 S141 H142 Q143 R175 L246 R247 K284 R290 L464 F469 K473 V485 V486 T490 V506 N509 Q513 H546 E576 T612 K613 R642 T670 P671 G709 A713 M715 K716

Enzyme Commision number

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding

PDB	RCSB:8wd8, PDBe:8wd8, PDBj:8wd8
PDBsum	8wd8
PubMed	38295801
UniProt	A0A0Q2M2Z1

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Structure of PDB 8wd8 Chain A Binding Site BS02