Structure of PDB 8w8f Chain A Binding Site BS02

Receptor Information
>8w8f Chain A (length=1426) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNGGCGRYQP
RIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGME
PRYARPEWMIVTVLPVPPLSVRPAVRNQDDLTHKLADIVKINNQLRRNEQ
NGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKG
KEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVT
PFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYK
VERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNAD
FDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAV
RKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLI
IPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSL
GTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIAD
SKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRIL
NDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEG
KRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGRE
GLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDG
LAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSN
AHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFH
INPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHL
RSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSL
GEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLG
QSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNV
YYEMPDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNC
IFNDDNAEKLVLRIRIMNDDDVFLRCIESNMLTDMTLQGIEQISKVYMHL
PQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSND
IVEIFTVLGIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHL
MAITRHGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLG
QLAPAGTGCFDLLLDAEKCKYGMEIP
Ligand information
Receptor-Ligand Complex Structure
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PDB8w8f Strcutures of co-transcriptional RNA capping enzymes on paused transcription complex
Resolution4.0 Å
Binding residue
(original residue number in PDB)		R67 V264 N272 R334 F431 D497 D499
Binding residue
(residue number reindexed from 1)		R57 V225 N227 R289 F386 D452 D454
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8w8f, PDBe:8w8f, PDBj:8w8f
PDBsum8w8f
PubMed38816438
UniProtA0A8D1DPV6

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