Structure of PDB 8w59 Chain A Binding Site BS02

Receptor Information

>8w59 Chain A (length=61) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMC
YTVITFKQKIF

Ligand information

InChI=1S/Zn/q+2

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Zn

Name

ZINC ION

PDB chain

8w59 Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8w59 Crystal structure of the RING domain of human XIAP
Resolution	1.339 Å
Binding residue (original residue number in PDB)	C465 H467 C481 C484
Binding residue (residue number reindexed from 1)	C31 H33 C47 C50
Annotation score	4

Enzymatic activity

Enzyme Commision number

2.3.2.27: RING-type E3 ubiquitin transferase.

External links

PDB	RCSB:8w59, PDBe:8w59, PDBj:8w59
PDBsum	8w59
PubMed
UniProt	P98170\|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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