Structure of PDB 8vzl Chain A Binding Site BS02

Receptor Information
>8vzl Chain A (length=646) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVE
TLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLALGVGDGVLLKAVAQ
ATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRD
IARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVL
AALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEV
PDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEE
AAFTCEYKYDGQRAQIHALEGGEVKIFSRNQADNTGKYPDIISRIPKIKL
PSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAF
DLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEF
LEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLV
VIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQ
SLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARG
LVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8vzl Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA.
Resolution2.41 Å
Binding residue
(original residue number in PDB)		R305 T415 G416 A418 T420 R451 G453 A455 Q457 S458 T639 T640 R641 K642 R768 G769 K770 G776 K795 G797 S850 L851 S852 P853 Y855 S869 L870
Binding residue
(residue number reindexed from 1)		R45 T155 G156 A158 T160 R191 G193 A195 Q197 S198 T379 T380 R381 K382 R508 G509 K510 G516 K535 G537 S590 L591 S592 P593 Y595 S609 L610
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
External links
PDB RCSB:8vzl, PDBe:8vzl, PDBj:8vzl
PDBsum8vzl
PubMed38522520
UniProtP18858|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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