Structure of PDB 8vuw Chain A Binding Site BS02

Receptor Information
>8vuw Chain A (length=311) Species: 556 (Dickeya chrysanthemi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVDVSVSIFINKIYGVNTLEQTYKVDGYIVAQWTGKPRKTPGDKPLIVEN
TQIERWINNGLWVPALEFINVVGSPDTGNKRLMLFPDGRVIYNARFLGSF
SNDMDFRLFPFDRQQFVLELEPFSYNNQQLRFSDIQVYTENIDNEEIDEW
WIRGKASTHISDIRYDHLSSVQPNQNEFSRITVRIDAVRNPSYYLWSFIL
PLGLIIAASWSVFWLESFSERLQTSFTLMLTVVAYAFYTSNILGRLPYTT
YIDQMIIAGYGSIFAAILLIIFAHHRQANGVEDDLLIQRSRLAFPLGFLA
IGCVLVIRFFT
Ligand information
Ligand IDDHL
InChIInChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2
InChIKeyUFULAYFCSOUIOV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04SCCN
OpenEye OEToolkits 1.5.0C(CS)N
CACTVS 3.341NCCS
FormulaC2 H7 N S
Name2-AMINO-ETHANETHIOL;
2,3-DESHYDROLANTHIONINE
ChEMBLCHEMBL602
DrugBankDB00847
ZINCZINC000008034121
PDB chain8vuw Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8vuw Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation.
Resolution3.19 Å
Binding residue
(original residue number in PDB)		E77 E131 Y175 H177 F188
Binding residue
(residue number reindexed from 1)		E67 E121 Y165 H167 F178
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8vuw, PDBe:8vuw, PDBj:8vuw
PDBsum8vuw
PubMed36385237
UniProtP0C7B7|ELIC_DICCH Cys-loop ligand-gated ion channel

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