Structure of PDB 8vds Chain A Binding Site BS02

Receptor Information
>8vds Chain A (length=640) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVE
TLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLALGVGDGVLLKAVAQ
ATGRQLESVRAEAAEKGDVGLVAENLMLPPPPLTASGVFSKFRDIARLTG
SASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQA
VSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRI
IPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCE
YKYDGQRAQIHALEGGEVKIFSRNQADNTGKYPDIISRIPKIKLPSVTSF
ILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLN
GESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVK
DSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYL
GRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALV
LPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDK
GISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8vds Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA.
Resolution2.79 Å
Binding residue
(original residue number in PDB)		R305 T415 G416 A418 T420 R451 G453 A455 Q457 S458 T639 R641 K642 R768 G769 K770 R771 G776 C794 K795 G797 S850 S852 P853 Y855 S869 L870
Binding residue
(residue number reindexed from 1)		R45 T149 G150 A152 T154 R185 G187 A189 Q191 S192 T373 R375 K376 R502 G503 K504 R505 G510 C528 K529 G531 S584 S586 P587 Y589 S603 L604
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
External links
PDB RCSB:8vds, PDBe:8vds, PDBj:8vds
PDBsum8vds
PubMed38522520
UniProtP18858|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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