Structure of PDB 8v9g Chain A Binding Site BS02

Receptor Information
>8v9g Chain A (length=265) Species: 573 (Klebsiella pneumoniae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFP
LAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQ
AAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTP
GDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAG
FPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDE
LVASVGQVITQLILS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8v9g Chain A Residue 305 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8v9g Restricted Rotational Flexibility of the C5 alpha-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase.
Resolution1.62 Å
Binding residue
(original residue number in PDB)		G92 P93 D94
Binding residue
(residue number reindexed from 1)		G73 P74 D75
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:8v9g, PDBe:8v9g, PDBj:8v9g
PDBsum8v9g
PubMed38511828
UniProtQ09HD0|BLAG5_KLEPN Beta-lactamase GES-5 (Gene Name=blaGES-5)

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