Structure of PDB 8v5r Chain A Binding Site BS02

Receptor Information
>8v5r Chain A (length=944) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQP
AVPLPDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKP
PAWAWAEGWTRYGPEGEAVPVAIPEERALVFAVAVCLAEGTCPTLAVAIS
PSAWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTDWQEQLVVGHNVSFD
RAHIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGISSWDW
LDISSVNSLAEVHRLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCA
QDVWATHEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLAE
AQGTYEELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQ
KEDLGPCSEEEEFQQDVMARACLQKLKGTTELLPKRPQHLPGHPGWYRKL
CPRLDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLVPG
RHHGNGPYNDVDIPGCWFFKLPHKDGNSCNVGSPFAKDFLPKMEDGTLQA
GSGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEG
LYGAILPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYT
LVGADVDSQELWIAAVLGDAHFAGMHGCTAFGWMTLQGRKSRGTDLHSKT
ATTVGISREHAKIFNYGRIYGAGQPFAERLLMQFNHRLTQQEAAEKAQQM
YAATKGLWKGGTESEMFNKLESIATSDIPRTPVLGCCISRALEPSAVQEE
FMTSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLV
REEDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLRK
EVTMDCKTPSNPTGMERRYGIPQGEALDIYQIIELTKGSLEKRS
Ligand information
Receptor-Ligand Complex Structure
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PDB8v5r Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		S306 R309 K561 M596 R597 N803 K806 R807 T849 G952 Y955 G956 A957 F961 T1094
Binding residue
(residue number reindexed from 1)		S232 R235 K435 M470 R471 N568 K571 R572 T614 G717 Y720 G721 A722 F726 T803
Gene Ontology
Molecular Function
GO:0002020 protease binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006264 mitochondrial DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0045004 DNA replication proofreading
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0000262 mitochondrial chromosome
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005760 gamma DNA polymerase complex
GO:0032991 protein-containing complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8v5r, PDBe:8v5r, PDBj:8v5r
PDBsum8v5r
PubMed38932681
UniProtP54098|DPOG1_HUMAN DNA polymerase subunit gamma-1 (Gene Name=POLG)

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