Structure of PDB 8v4x Chain A Binding Site BS02

Receptor Information

>8v4x Chain A (length=367) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLT
EYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSE
NCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIV
FGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMG
KCHLTKGKQALEIRSSLSEKRALTDPIQGVRNLQWAKAHELPESMCLKFD
CGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKD
ANKGTPEETGSYLVKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVE
DKQEVNVGKPLIAKLDM

Ligand information

>8v4x Chain H (length=5) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tVRPR

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8v4x Inhibition of MALT1 and BCL2 induces synergistic anti-tumor activity in models of B cell lymphoma.
Resolution	2.486 Å
Binding residue (original residue number in PDB)	C464 H540 L541
Binding residue (residue number reindexed from 1)	C127 H203 L204

Enzymatic activity

Enzyme Commision number

3.4.22.-

Gene Ontology

	Molecular Function
GO:0004197	cysteine-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:8v4x, PDBe:8v4x, PDBj:8v4x
PDBsum	8v4x
PubMed	38507740
UniProt	Q9UDY8\|MALT1_HUMAN Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Gene Name=MALT1)

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