Structure of PDB 8v2t Chain A Binding Site BS02

Receptor Information

>8v2t Chain A (length=191) Species: 357348 (Burkholderia pseudomallei 1106a)

LTYITNSIAEAQRVMAAMLADERLLATVRKVADACIASIAQGGKVLLAGN
GGSAADAQHIAGEFVSRFAFDRPGLPAVALTTDTSILTAIGNDYGYEKLF
SRQVQALGNEGDVLIGYSTSGKSPNILAAFREAKAKGMTCVGFTGNRGGE
MRELCDLLLEVPSADTPKIQEGHLVLGHIVCGLVEHSIFGK

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 8v2t Chain A Residue 202

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8v2t Potentiating Activity of GmhA Inhibitors on Gram-negative Bacteria
• Resolution: 1.402 Å
• Binding residue (original residue number in PDB): H64 E68 H183
• Binding residue (residue number reindexed from 1): H59 E63 H178
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.3.1.28: D-sedoheptulose-7-phosphate isomerase.

Gene Ontology

Molecular Function

• GO:0008270 zinc ion binding
• GO:0008968 D-sedoheptulose 7-phosphate isomerase activity
• GO:0016853 isomerase activity
• GO:0046872 metal ion binding
• GO:0097367 carbohydrate derivative binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0045227 capsule polysaccharide biosynthetic process
• GO:1901135 carbohydrate derivative metabolic process
• GO:2001061 D-glycero-D-manno-heptose 7-phosphate biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8v2t, PDBe:8v2t, PDBj:8v2t
• PDBsum: 8v2t
• PubMed: 38598312
• UniProt: Q93UJ2|GMHA_BURPS Phosphoheptose isomerase (Gene Name=gmhA)