Structure of PDB 8uzb Chain A Binding Site BS02

Receptor Information
>8uzb Chain A (length=910) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRYKIGLAIGITSVGWAVMNLDIPRIEDLGVRIFDRAENPQTGESLALPR
RLARSARRRLRRRKHRLERIRRLVIREGILTKEELDKLFEEKHEIDVWQL
RVEALDRKLNNDELARVLLHLAKRRGFKSNRKSSTMLKHIEGNRAILSSY
RTVGEMIVKDPKFALHKRNKGENYINTIARDDLEREIRLIFSKQREFGDM
SCTEEFENEYITIWASQRPVASKDDIEKKVGFCTFEPKEKRAPKATYTFQ
SFIAWEHINKLRLISPSGARGLTDEERRLLYEQAFQKNKITYHDIRTLLH
LPDDTYFKGIVYDRGESRKQNENIRFLELDAYHQIRKAVDKVYGKGKSSS
FLPIDFDTFGYALTLFKDDADIHSYLRNEYEQNGKRMPNLANKVYDNELI
EELLNLSFTKFGHLSLKALRSILPYMEQGEVYSSACERAGYTFTGPKKKQ
KTMLLPNIQPIANPVVMRALTQARKVVNAIIKKYGSPVSIHIELARDLSQ
TFDERRKTKKEQDENRTRYISRFFANFIREHLKFAESDDKQKVYTVNGRV
TAHLRSRWEFNKNREESDLHHAVDAVIVACTTPSDIAKVTAFYQRREQNE
PHFPQPWPHFADELRARLSKHPKESIKALNLGNYDDQKLESLQPVFVSRM
PKRSVTGAAHRETLRRYVGIDERSGKIQTVVKTKLSKIKLDASGHFPMYG
KESDPRTYEAIRQRLLEHNNDPKKAFQGPLYKPKKNGEPGPVIRTVKIID
TRNQVIPLNDGKTVAYNSNIVRVDVFEKDGKYYCVPVYTMDIMKGILPNK
AIEPNKPYSEWKEMTEDYTFRFSLYPNDLIRIELPREKTVKTAAGEEINV
KDVFVYYKTIDSANGGLELISHDHRFSLRGVGSRTLKRFEKYQVDVLGNI
YKVRGEKRVG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8uzb Accelerated DNA unwinding supercharges genome editing by engineered CRISPR-Cas9
Resolution2.63 Å
Binding residue
(original residue number in PDB)		S129 N130 R131 K132 M143 E179 Y181 I233 K236 V237 R248 K267 R269 K315 G316 K374 T416 K417 F418 S440 F450 E818 T819 N1020 R1035 G1036 V1037 G1038 R1040 T1041
Binding residue
(residue number reindexed from 1)		S129 N130 R131 K132 M136 E172 Y174 I226 K229 V230 R241 K260 R262 K308 G309 K367 T409 K410 F411 S433 F443 E662 T663 N864 R879 G880 V881 G882 R884 T885
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8uzb, PDBe:8uzb, PDBj:8uzb
PDBsum8uzb
PubMed38781968
UniProtA0A150MP45

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