Structure of PDB 8uxx Chain A Binding Site BS02

Receptor Information
>8uxx Chain A (length=400) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASFNVPIIMDNGTGYSKLGYAGNDAPSYVFPTVIATRSKRATEDLDFFIG
NDALKKASAGYSLDYPIRHGQIENWDHMERFWQQSLFKYLRCEPEDHYFL
LTEPPLNPPENRENTAEIMFESFNCAGLYIAVQAVLALAASWTSSKVTDR
SLTGTVVDSGDGVTHIIPVAEGYVIGSSIKTMPLAGRDVTYFVQSLLRDR
NEPDSSLKTAERIKEECCYVCPDIVKEFSRFDREPDRYLKYASESITGHS
TTIDVGFERFLAPEIFFNPEIASSDFLTPLPELVDNVVQSSPIDVRKGLY
KNIVLSGGSTLFKNFGNRLQRDLKRIVDERIHRSEMLSGAKSGGVDVNVI
SHKRQRNAVWFGGSLLAQTPEFGSYCHTKADYEEYGASIARRYQIFGNSL
Ligand information
Ligand IDBEF
InChIInChI=1S/Be.3FH/h;3*1H/q+2;;;/p-3
InChIKeyOGIAHMCCNXDTIE-UHFFFAOYSA-K
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[Be-](F)(F)F
ACDLabs 10.04
CACTVS 3.341		F[Be-](F)F
FormulaBe F3
NameBERYLLIUM TRIFLUORIDE ION
ChEMBL
DrugBank
ZINC
PDB chain8uxx Chain A Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8uxx High resolution cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by the Arp2/3 complex
Resolution3.2 Å
Binding residue
(original residue number in PDB)		G13 T14 G187 D188 G189
Binding residue
(residue number reindexed from 1)		G12 T13 G160 D161 G162
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0051015 actin filament binding
Biological Process
GO:0006897 endocytosis
GO:0030036 actin cytoskeleton organization
GO:0030041 actin filament polymerization
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0044396 actin cortical patch organization
GO:0090135 actin filament branching
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0030479 actin cortical patch
GO:0032153 cell division site
GO:0051285 cell cortex of cell tip

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uxx, PDBe:8uxx, PDBj:8uxx
PDBsum8uxx
PubMed38448439
UniProtP32390|ARP3_SCHPO Actin-related protein 3 (Gene Name=act2)

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