Structure of PDB 8uw3 Chain A Binding Site BS02

Receptor Information
>8uw3 Chain A (length=1265) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHITILTLNINGLNSAIKRHRLASWIKSQDPSVCCIQETHLTCRDTHRLK
IKGWRKIYQANGKQKKAGVAILVSDKTDFKPTKIKRDKEGHYIMVKGSIQ
QEELTILNIYAPNTGAPRFIKQVLSDLQRDLDSHTLIMGDFNTPLSTLDR
STRQKVNKDTQELNSALHQADLIDIYRTLHPKSTEYTFFSAPHHTYSKID
HIVGSKALLSKCKRTEIITNYLSDHSAIKLELRIKNSTTWKLNNLLLNDY
WVHNEMKAEIKMFFETNENKDTTYQNLWDAFKAVCRGKFIALNAHKRKQE
RSKIDTLTSQLKELEKQEQTHSKASRRQEITKIRAELKEIETQKTLQKIN
ESRSWFFERINKIDRPLARLIKKKREKNQIDTIKNDKGDITTDPTEIQTT
IREYYKHLYANKLENLEEMDKFLDTYTLPRLNQEEVESLNRPITGSEIVA
IINSLPTKKSPGPDGFTAEFYQRYKEELVPFLLKLFQSIEKEGILPNSFY
EASIILIPKPGRDTTKKENFRPISLMNIDAKILNKILANRIQQHIKKLIH
HDQVGFIPGMQGWFNIRKSINVIQHINRAKDKNHMIISIDAEKAFDKIQQ
PFMLKTLNKLGIDGTYFKIIRAIYDKPTANIILNGQKLEAFPLKTGTRQG
CPLSPLLFNIVLEVLARAIRQEKEIKGIQLGKEEVKLSLFADDMIVYLEN
PIVSAQNLLKLISNFSKVSGYKINVQKSQAFLYTNNRQTESQIMGELPFT
IASKRIKYLGIQLTRDVKDLFKENYKPLLKEIKEETNKWKNIPCSWVGRI
NIVKMAILPKVIYRFNAIPIKLPMTFFTELEKTTLKFIWNQKRARIAKSI
LSQKNKAGGITLPDFKLYYKATVTKTAWYWYQNRDIDQWNRTEPSEIMPH
IYNYLIFDKPEKNKQWGKDSLFNKWCWENWLAICRKLKLDPFLTPYTKIN
SRWIKDLNVKPKTIKTLEENLGITIQDIGVGKDFMSKTPKAMATKDKIDK
WDLIKLKSFCTAKETTIRVNRQPTTWEKIFATYSSDKGLISRIYNELKQI
YKKKTNNPIKKWAKDMNRHFSKEDIYAAKKHMKKCSSSLAIREMQIKTTM
RYHLTPVRMAIIKKSGNNRCWRGCGEIGTLLHCWWDCKLVQPLWKSVWRF
LRDLELEIPFDPAIPLLGIYPNEYKSCCYKDTCTRMFIAALFTIAKTWNQ
PKCPTMIDWIKKMWHIYTMEYYAAIKNDEFISFVGTWMKLETIILSKLSQ
EQKTKHRIFSLIGGN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8uw3 Template and target site recognition by human LINE-1 in retrotransposition
Resolution3.2 Å
Binding residue
(original residue number in PDB)		D374 R375 A378 F566 F700 L769 M815 Y823
Binding residue
(residue number reindexed from 1)		D364 R365 A368 F556 F690 L759 M805 Y813
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
3.1.21.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0003964 RNA-directed DNA polymerase activity
GO:0004519 endonuclease activity
GO:0009036 type II site-specific deoxyribonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process
GO:0006310 DNA recombination
GO:0032197 retrotransposition
GO:0090304 nucleic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8uw3, PDBe:8uw3, PDBj:8uw3
PDBsum8uw3
PubMed38096901
UniProtO00370|LORF2_HUMAN LINE-1 retrotransposable element ORF2 protein

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