Structure of PDB 8uvu Chain A Binding Site BS02

Receptor Information
>8uvu Chain A (length=379) Species: 7091 (Bombyx mori) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TPCLVGGAHAFILKISSFCGLAPLRFEPRSQEYAVTISKGKCFYSYILVT
FLVICTIYGLVAEIGVGVEKSVRMSSRMSQVVSACDILVVAVTAGVGVYG
APARMRTMLSYMENIVAVDRELGRHHSAATERKLCALLLLILLSFTILLV
DDFCFYAMQAGKTGRQWEIVTNYAGFYFLWYIVMVLELQFAFTALSLRAR
LKLFNEALNVTASQCLQVPPCEAVGRLSRMRCTLCEVTRHIADGYGLPLV
IILMSTLLHLIVTPYFLIMEIIVSTHRLHFLVLQFLWCTTHLIRMLVVVE
PCHYTIREGKRTEDILCRLMTLAPHGGVLSSRLEVLSRLLMLQNISYSPL
GMCTLDRPLMVTVLGAVTTYLVILIQFQR
Ligand information
Ligand IDFRU
InChIInChI=1S/C6H12O6/c7-1-3-4(9)5(10)6(11,2-8)12-3/h3-5,7-11H,1-2H2/t3-,4-,5+,6-/m1/s1
InChIKeyRFSUNEUAIZKAJO-ARQDHWQXSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04OC1C(O)C(OC1(O)CO)CO
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@](O1)(CO)O)O)O)O
CACTVS 3.341OC[CH]1O[C](O)(CO)[CH](O)[CH]1O
OpenEye OEToolkits 1.5.0C(C1C(C(C(O1)(CO)O)O)O)O
CACTVS 3.341OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O
FormulaC6 H12 O6
Namebeta-D-fructofuranose;
beta-D-fructose;
D-fructose;
fructose
ChEMBLCHEMBL604608
DrugBank
ZINCZINC000001529270
PDB chain8uvu Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8uvu The molecular basis of sugar detection by an insect taste receptor.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R86 D99 F189 W193 T330 F333 Q351 W354 H358
Binding residue
(residue number reindexed from 1)		R73 D86 F176 W180 T263 F266 Q284 W287 H291
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0099094 ligand-gated monoatomic cation channel activity
GO:0170021 ionotropic taste receptor activity
Biological Process
GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste
GO:0007165 signal transduction
GO:0007635 chemosensory behavior
GO:0008049 male courtship behavior
GO:0050909 sensory perception of taste
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0043025 neuronal cell body

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8uvu, PDBe:8uvu, PDBj:8uvu
PDBsum8uvu
PubMed38447670
UniProtB3GTD7

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