Structure of PDB 8urb Chain A Binding Site BS02

Receptor Information
>8urb Chain A (length=921) Species: 28295 (Porcine epidemic diarrhea virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DMAYLNRVRGSSAARLEPCNGTDTQHVYRAFDIYNKDVACLGKFLKVNCV
RLKNLDKHDAFYVVKRCTKSAMEHEQSIYSRLEKCGAVAEHDFFTWKDGR
AIYGNVCRKDLTEYTMMDLCYALRNFDENNCDVLKSILIKVGACEESYFN
NKVWFDPVENEDIHRVYALLGTIVSRAMLKCVKFCDAMVEQGIVGVVTLD
NQDLNGDFYDFGDFTCSIKGMGIPICTSYYSYMMPVMGMTNCLASECFVK
SDIFGEDFKSYDLLEYDFTEHKTALFNKYFKYWGLQYHPNCVDCSDEQCI
VHCANFNTLFSTTIPITAFGPLCRKCWIDGVPLVTTAGYHFKQLGIVWNN
DLNLHSSRLSINELLQFCSDPALLIASSPALVDQRTVCFSVAALGTGMTN
QTVKPGHFNKEFYDFLLEQGFFSEGSELTLKHFFFAQKGDAAVKDFDYYR
YNRPTVLDICQARVVYQIVQRYFDIYEGGCITAKEVVVTNLNKSAGYPLN
KFGKAGLYYESLSYEEQDELYAYTKRNILPTMTQLNLKYAISGKERARTV
GGVSLLSTMTTRQYHQKHLKSIVNTRGASVVIGTTKFYGGWDNMLKNLID
GVENPCLMGWDYPKCDRALPNMIRMISAMILGSKHTTCCSSTDRFFRLCN
ELAQVLTEVVYSNGGFYLKPGGTTSGDATTAYANSVFNIFQAVSANVNKL
LSVDSNVCHNLEVKQLQRKLYECCYRSTTVDDQFVVEYYGYLRKHFSMMI
LSDDGVVCYNNDYASLGYVADLNAFKAVLYYQNNVFMSASKCWIEPDINK
GPHEFCSQHTMQIVDKDGTYYLPYPDPSRILSAGVFVDDVVKTDAVVLLE
RYVSLAIDAYPLSKHENPEYKKVFYVLLDWVKHLYKTLNAGVLESFSVTL
LEDSTAKFWDESFYANMYEKS
Ligand information
>8urb Chain J (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaaaaucugugauuuuaauag
.....................
Receptor-Ligand Complex Structure
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PDB8urb An alphacoronavirus polymerase structure reveals conserved co-factor functions.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		K495 S496 K540 R564 K572 T587 F589 S677 G678 D679 A680 Y684
Binding residue
(residue number reindexed from 1)		K493 S494 K538 R562 K570 T585 F587 S675 G676 D677 A678 Y682
Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
3.4.19.12: ubiquitinyl hydrolase 1.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8urb, PDBe:8urb, PDBj:8urb
PDBsum8urb
PubMed36993498
UniProtU6BRU0

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