Structure of PDB 8umy Chain A Binding Site BS02

Receptor Information
>8umy Chain A (length=546) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NPVLRRPPILEDYVHVTSTEGVRAYLVLRASSHCLWVDEFAPRHYTELLS
DDFTNRCLLKWLKLWDLVVFGHERPSSHEQVLEEMLEAGLDPSQRPKQKV
ALLCGPPGLGKTTLAHVIARHAGYSVVEMNASDDRSPEVFRTRIEAATQM
ESVLGAGGKPNCLVIDEIDGAPVAAINVLLSILNRKGLLMRPIICICNDQ
FAPSLRQLKQQAFLLHFPPTLPSRLVQRLQEVSLRQGMRADPGVLAALCE
KTDNDIRACINTLQFLYSRGQRELSVRDVQATRVGLKDQRRGLFSVWQEV
FQLPRASLTSASQRFYRVLHAAASAGEHEKVVQGLFDNFLRLRLRDSSLG
AVCVALDWLAFDDLLAGAAHHSQSFQLLRYPPFLPVAFHVLFASSHTPRI
TFPSSQQEAQNRMSQMRNLIQTLVSGIAPATRSRATPQALLLDALCLLLD
ILAPKLRPVSTQLYSTREKQQLASLVGTMLAYSLTYRQERTPDGQYIYRL
EPNVEELCRFPELPARKPLTYQTKQLIAREIEVEKMRRAEASARVE
Ligand information
Receptor-Ligand Complex Structure
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PDB8umy Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC.
Resolution2.83 Å
Binding residue
(original residue number in PDB)		F692 R696
Binding residue
(residue number reindexed from 1)		F375 R379
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0032508 DNA duplex unwinding
GO:1900264 positive regulation of DNA-directed DNA polymerase activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0031390 Ctf18 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8umy, PDBe:8umy, PDBj:8umy
PDBsum8umy
PubMed38669181
UniProtQ8WVB6|CTF18_HUMAN Chromosome transmission fidelity protein 18 homolog (Gene Name=CHTF18)

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