Structure of PDB 8uha Chain A Binding Site BS02

Receptor Information
>8uha Chain A (length=1417) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDPR
QGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVC
FFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGCGRY
QPRIRRSGLELYAEWKKILLSPERVHEIFKRISDEECFVLGMEPRYARPE
WMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQN
GAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGK
EGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTP
FNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKV
ERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADF
DGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVR
KFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLII
PGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLG
TSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADS
KTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILN
DARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGK
RIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREG
LIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGL
AGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNA
HIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHI
NPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHLR
STLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLG
EPATQMTLNKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAK
DILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMPDFDVA
RISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKL
VLRIRIMNSDDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKK
IIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVL
GIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGV
NRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTG
CFDLLLDAEKCKYGMEI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8uha Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		K331 K1132 H1417
Binding residue
(residue number reindexed from 1)		K285 K1077 H1348
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uha, PDBe:8uha, PDBj:8uha
PDBsum8uha
PubMed38401543
UniProtA0A8D1DPV6

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