Structure of PDB 8ud3 Chain A Binding Site BS02

Receptor Information

>8ud3 Chain A (length=346) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2)

SLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLP
VNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIG
VCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKG
LQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNL
QEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEAIVYGDFSHSQLGGLHL
LIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLD
DFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQ

Ligand information

>8ud3 Chain H (length=17)

aaaaaaaaaaaaaaaaa

.................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ud3 Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15.
• Resolution: 2.67 Å
• Binding residue (original residue number in PDB): H242 S243 S315 V317 W332
• Binding residue (residue number reindexed from 1): H242 S243 S315 V317 W332

Enzymatic activity

• Enzyme Commision number: 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
  2.1.1.57: methyltransferase cap1.
  2.7.7.48: RNA-directed RNA polymerase.
  2.7.7.50: mRNA guanylyltransferase.
  3.1.13.-
  3.4.19.12: ubiquitinyl hydrolase 1.
  3.4.22.-
  3.4.22.69: SARS coronavirus main proteinase.
  3.6.4.12: DNA helicase.
  3.6.4.13: RNA helicase.
  4.6.1.-

External links

• PDB: RCSB:8ud3, PDBe:8ud3, PDBj:8ud3
• PDBsum: 8ud3
• PubMed: 38613382
• UniProt: P0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)