Structure of PDB 8u3h Chain A Binding Site BS02

Receptor Information
>8u3h Chain A (length=425) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSKKYQWDAETQGWILG
SFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGP
LIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVIS
LPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEK
EYILSSLRNQLSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLP
TYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLCV
RRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSIN
HLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIA
AAINVFGAIFFTLFAKGEVQNWALN
Ligand information
Ligand IDLEU
InChIInChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
InChIKeyROHFNLRQFUQHCH-YFKPBYRVSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC(C)C[C@@H](C(=O)O)N
CACTVS 3.341CC(C)C[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0CC(C)CC(C(=O)O)N
ACDLabs 10.04O=C(O)C(N)CC(C)C
CACTVS 3.341CC(C)C[CH](N)C(O)=O
FormulaC6 H13 N O2
NameLEUCINE
ChEMBLCHEMBL291962
DrugBankDB00149
ZINCZINC000003645145
PDB chain8u3h Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8u3h Structure of Fmoc-Leu-OH bound Sialin
Resolution3.67 Å
Binding residue
(original residue number in PDB)		M342 S407
Binding residue
(residue number reindexed from 1)		M279 S344
Annotation score2
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005351 carbohydrate:proton symporter activity
GO:0015136 sialic acid transmembrane transporter activity
GO:0015293 symporter activity
GO:0015538 sialic acid:proton symporter activity
GO:0022857 transmembrane transporter activity
GO:0042880 D-glucuronate transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006820 monoatomic anion transport
GO:0006865 amino acid transport
GO:0009617 response to bacterium
GO:0015739 sialic acid transport
GO:0034219 carbohydrate transmembrane transport
GO:0042874 D-glucuronate transmembrane transport
GO:0098700 neurotransmitter loading into synaptic vesicle
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0030672 synaptic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0045202 synapse
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8u3h, PDBe:8u3h, PDBj:8u3h
PDBsum8u3h
PubMed
UniProtQ9NRA2|S17A5_HUMAN Sialin (Gene Name=SLC17A5)

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