Structure of PDB 8tqb Chain A Binding Site BS02

Receptor Information

>8tqb Chain A (length=744) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEI
NKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKLLIAGVIGGS
YSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAK
AMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGR
SNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVA
SDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNP
WFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYA
MAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKG
ADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHW
SRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDC
GPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFI
SGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSAL
LTKTKFISPSSQVFICLGLILVQIVMVILETPGTRRYTLPEKRETVILKC
NVKDSSMLISLTYDVVLVILCTVYAFKTEAKFIGFTMYTTCIIWLAFLPI
FYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQK

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

8tqb Chain A Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8tqb Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization.
Resolution	3.3 Å
Binding residue (original residue number in PDB)	S152 Y222 R277
Binding residue (residue number reindexed from 1)	S103 Y173 R228
Annotation score	4

External links

PDB	RCSB:8tqb, PDBe:8tqb, PDBj:8tqb
PDBsum	8tqb
PubMed	37645747
UniProt	P31422\|GRM3_RAT Metabotropic glutamate receptor 3 (Gene Name=Grm3)

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